Lindsay Sherbert added 18 points and Haiden Palmer 17 for the Bulldogs (26-4, 16-2), who wrapped up their 10th-straight West Coast Conference title in their last game and went 16-0 at home.
KiKi Moore kept Pacific (17-11, 12-6), which had a six-game winning streak end, in the game by matching her career-high of 33 points. Hailie Eackles added 20 and Kendall Kenyon 12 with 10 rebounds.
Gonzaga went on a 17-3 tear in the first half to open a 27-10 lead but the Tigers came back to close within 39-34 at the half. Pacific's last lead was 53-51 with 12:28 to go but Palmer scored the next four, followed by a Sherbert layup.
GU had a 50-34 rebound advantage (24-10 offensive) and 28-2 in bench points.