Cal (17-7, 9-4 Pac-12) used a 13-2 run to lead 27-16 with 5:07 left in the first half, and Arizona (5-19, 1-12) couldn't cut the deficit to single digits from that point forward.
Gennifer Brandon added 10 points and nine rebounds for Cal, as the Bears extended their win streak to three games.
Breanna Workman, Erica Barnes, and Keyahndra Cannon each scored 10 for Arizona. The Wildcats, coming off a win over ranked rival Arizona State last Sunday, suffered their 15th straight loss to Cal.
Brittany Boyd, named to five national award midseason watch lists, suffered an ankle injury in the second half and did not return. Arizona's Carissa Crutchfield was also hurt in the game and had to be carried off the court in the game's final minute.