The company said in a Twitter message that it's working to resolve the problem, which is not affecting the Fox high-definition channel.
Hundreds of football fans are taking to Twitter to complain about the blackout, which occurred shortly before the halftime show. Two other Time Warner cable channels—KCAL-TV and KTLA-TV—were also blacked out.
It wasn't immediately clear how many customers were affected by the blackout.
Calls and email messages to Time Warner Cable spokesmen were not immediately returned.
The Seattle Seahaws were leading 22-0 over the Denver Broncos at halftime.